Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5736197 | Brain Research Bulletin | 2017 | 9 Pages |
Abstract
This study aims to clarify the neuroprotective effect of naringin on early brain injury (EBI) following subarachnoid hemorrhage (SAH) and the possible mechanisms of naringin in the treatment of SAH. The endovascular puncture model was performed to induce SAH model in rats and the efficacy of 40Â mg/kg and 80Â mg/kg naringin were tested by intraperitoneally administration. SAH grade, neurological score, brain edema, blood-brain barrier permeability, the changes of oxidative stress related factors, apoptosis-related proteins, mitogen-activated protein kinase (MAPK) signaling pathway and neuronal morphology were detected to analyze the potential effect of naringin against SAH. The results demonstrated that naringin significantly ameliorated EBI, including SAH severity, neurologic deficits, brain edema and blood-brain barrier integrity by attenuating SAH-induced oxidative stress and apoptosis, and reduced the oxidant damage and apoptosis by inhibiting the activation of MAPK signaling pathway, which suggested a therapeutic potential of naringin in providing neuroprotection after SAH.
Keywords
MDAMCAICAECAEBISAHCATGSHGSSGDMSOGSH-PxMAPKEarly brain injuryEvans BlueOxidative stressApoptosisSubarachnoid hemorrhageDimethyl sulfoxideSODBBBSuperoxide dismutasemiddle cerebral arteryCarotid arteryinternal carotid arterymalondialdehydeBlood-brain barrierNaringinmitogen-activated protein kinaseCatalaseGlutathioneoxidized glutathioneglutathione peroxidase
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Authors
Yuwei Han, Jingyuan Su, Xiujuan Liu, Yuan Zhao, Chenchen Wang, Xiaoming Li,