Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats

Article ID	Journal	Published Year	Pages	File Type
5736353	Brain Research Bulletin	2017	9 Pages	PDF

Abstract

In conclusion, DEX induced protective effects against cerebral ischemia-induced brain and erythrocyte oxidative injuries through regulation of the antioxidant level and cytokine production. However, both doses of DEX induced oxidative toxicity and apoptotic effects in the rats' livers.

Keywords

GSH IL-1β ISC NF-kB PARP TBAR DEX MDA GSH-Px ROS Ischemia Cerebral ischemia Interleukin-1β Oxidative stress tumor necrosis factor-alpha Dexmedetomidine Cytokine TNF-α nuclear factor kappa B malondialdehyde Brain poly (ADP-ribose) polymerase reduced glutathione Liver glutathione peroxidase Reactive oxygen species