Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus

Article ID	Journal	Published Year	Pages	File Type
5736596	Brain Research	2017	13 Pages	PDF

Abstract

Syk appears unlikely to be the major kinase that phosphorylates tyrosine 18 of tau in tauopathy. It possibly phosphorylates tyrosine 18 of tau and regulates other tau kinases in neurons with a fibrillary tau pathology.

Keywords

NFTs FTDP-17 GSK3β GVD AT100 Syk Alzheimer’s disease standard error of the mean Granulovacuolar degeneration frontotemporal dementia with Parkinsonism linked to chromosome 17 spleen tyrosine kinase Non-receptor tyrosine kinase SEM neurofibrillary tangles Glycogen synthase kinase-3β