| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5736674 | Brain Research | 2017 | 19 Pages |
Abstract
Intrastriatal BoNT-A injection did not alter the number of ChAT-ir interneurons irrespective of survival time and dosage tested. However, the numeric density of the ChAT-ir BiVs at a dose of 25Â pg increased from 1 to 3Â months after BoNT-A, followed by a time dependent decrease. In parallel, with increasing BoNT-A survival time, the mean BiV volume increased as the number of small BiVs decreased. Interestingly, in contrast to rats we did not find TH-ir BiVs in BoNT-A injected mouse striatum.
Keywords
6-OHDACPU6-HydroxydopamineSNAP-25SV2BoNT-Acaudate-putamenl-3,4-dihydroxyphenylalaninel-DOPASNpcAChStriatumunbiased stereologyAcetylcholineimmunoreactiveInterneuronParkinson’s diseasesubstantia nigrasubstantia nigra pars compactatyrosine hydroxylaseDopaminebasal gangliaMouse brainChATcholine acetyltransferase
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Authors
Alexander Hawlitschka, Carsten Holzmann, Sarah Witt, Juliane Spiewok, Anne-Marie Neumann, Oliver Schmitt, Andreas Wree, Veronica Antipova,