Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5736705 | Brain Research | 2017 | 5 Pages |
â¢Cytosolic phospholipase A2 alpha (cPLA2α) regulates integrity of the cell membrane and inflammation.â¢Semi-knockout of cPLA2α in APP/PS1 transgenic mice reduces the plaque formation and gliosis.â¢cPLA2α plays a complex role in AD pathogenesis.
Cytosolic phospholipase A2α (cPLA2α) is a key enzyme in regulation of inflammation process and neuromembrane homeostasis, both of which are critical in pathogenesis of Alzheimer's diseases. By hybride APP/PS1 Tg-AD mice with cPLA2α knockout mice, three lines of APP/PS1 Tg-AD mice were produced with genotypes of cPLA2α+/+, cPLA2α+/â and cPLA2αâ/â. Compared to cPLA2α+/+ Tg-AD mice, the amyloid plaque formation was significantly downregulated in the brain of cPLA2α+/â Tg-AD mice, but not in cPLA2αâ/â Tg-AD mice. The reactive gliosis were also significantly downregulated in both cPLA2α+/â and cPLA2αâ/â Tg-AD mouse lines. The paradoxical effects of cPLA2α on the amyloid plaques reveal a complex role of cPLA2α in pathogenesis of AD and could be a potential target for prevention and treatment of AD.