| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5736947 | Current Opinion in Neurobiology | 2017 | 6 Pages |
â¢Dedifferentiated Schwann cells are required for the regeneration of multiple tissues in mammals and amphibians.â¢Dedifferentiated Schwann cells originate from injured nerves and migrate into damaged tissues.â¢Dedifferentiated Schwann cells promote regeneration through paracrine growth factor secretion.â¢Sox2 expression regulates dedifferentiated Schwann cell activity during tissue repair and regeneration.
Current evidence suggests that peripheral nerve-associated Schwann cells possess the capacity to promote the repair and regeneration of multiple tissue types, in addition to peripheral nervous system axons. These findings shed light on the nerve-dependent nature of regeneration that has been well documented in various organs. This review outlines recent advances in knowledge surrounding endogenous regenerative functions of Schwann cells across species and tissue types, with a specific focus on the role of Sox2+ dedifferentiated Schwann cells in regulating the proliferation of surrounding tissue-resident mesenchymal precursors.
