Article ID Journal Published Year Pages File Type
5736948 Current Opinion in Neurobiology 2017 7 Pages PDF
Abstract
Glia adopt remarkable shapes that are tightly coordinated with the morphologies of their neuronal partners. To achieve these precise shapes, glia and neurons exhibit coordinated morphological changes on the time scale of minutes and on size scales ranging from nanometers to hundreds of microns. Here, we review recent studies that reveal the highly dynamic, localized morphological changes of mammalian neuron-glia contacts. We then explore the power of Drosophila and C. elegans models to study coordinated changes at defined neuron-glia contacts, highlighting the use of innovative genetic and imaging tools to uncover the molecular mechanisms responsible for coordinated morphogenesis of neurons and glia.
Related Topics
Life Sciences Neuroscience Neuroscience (General)
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