| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5737038 | Current Opinion in Neurobiology | 2017 | 8 Pages |
Abstract
Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression. microRNAs (miRNAs) have emerged as essential regulators of gene expression. They are small non-coding RNAs that regulate mRNA stability and translation by interacting with the 3â² untranslated region (3â² UTR) of mRNAs. miRNAs are located to neuronal processes to regulate protein synthesis locally and their expression is regulated by synaptic activity. This article reviews recent findings on the role of miRNAs in synapse development and synaptic plasticity.
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Authors
Zhonghua Hu, Zheng Li,