Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5737595 | Neuroscience | 2017 | 17 Pages |
Abstract
Taken together, this study showed that traumatic stress and subsequent PET involves an event-dependent alteration of IGF1/IGF-1R/CaMKIIα. Firstly, we showed a direct relationship between IGF-1/IGF-1R expression, presynaptic function (synaptophysin) and neurotransmitter activity in stress and PET. Secondly, we identified the possible role of CaMKIIα in post-synaptic function and regulation of small ion conductance channels. Lastly, we highlighted some of the possible links between IGF1/IGF-1R/CaMKIIα, the expression of DAMP proteins, Microglia activation, and its implication on synaptic plasticity during stress and PET.
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Authors
Olalekan M. Ogundele, Philip J. Ebenezer, Charles C. Lee, Joseph Francis,