Article ID Journal Published Year Pages File Type
5737645 Neuroscience 2017 9 Pages PDF
Abstract
BoNT/A antinociceptive activity is absent in animals lacking the SP and neurokinin 1 receptor encoding genes, in spite of presence of toxin's enzymatic activity in central sensory regions. Thus, we conclude that the integrity of SP-ergic system is necessary for the antinociceptive activity of BoNT/A.
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Life Sciences Neuroscience Neuroscience (General)
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Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice
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