| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5737823 | Neuroscience | 2017 | 9 Pages |
Abstract
In this study, myelin-induced inhibition of neurite outgrowth was established in a spiral ganglion model. We reveal that 7,8-DHF is a viable novel compound for the stimulation of neurite outgrowth in a myelin-induced inhibitory environment. The combination of TrkB stimulation and ROCK inhibition can be used to overcome myelin inhibition.
Keywords
PI3KB27K252aNMRIMLCKNgRY27632p75NF-2007,8-DHFneurofilament 200SGNNDSPFADAPIMAGCREBPBSRhoAGFAP4′,6-diamidino-2-phenylindol7,8-DihydroxyflavoneBDNFBSAcAMPMAPKAdenosine TriphosphateATPCyclic adenosine monophosphatebovine serum albuminscala tympaniTrkmyosin light chain kinasenormal donkey serumBrain-derived neurotrophic factorPhosphatidylinositol 3-kinasespiral ganglionPhosphate-buffered salinenaval medical research instituteNeurotrophinspiral ganglion neuronNogoparaformaldehydeGlial fibrillary acidic proteincAMP response element-binding proteinmitogen-activated protein kinaseCochlear implantnegative controlMyelin-associated glycoproteinNogo receptorTyrosine kinase receptorp75 neurotrophin receptorRock
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Authors
Benedikt Kramer, Anke Tropitzsch, Marcus Müller, Hubert Löwenheim,