Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5737950 | Neuroscience | 2017 | 51 Pages |
Abstract
Stress-induced neural injuries are closely linked to the pathogenesis of various neuropsychiatric disorders and psychosomatic diseases. We and others have previously demonstrated certain protective effects of epigallocatechin-3-gallate (EGCG) in stress-induced cerebral impairments, but the underlying protective mechanisms still remain poorly elucidated. Here we provide evidence to support the possible involvement of PKCα and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways in EGCG-mediated protection against restraint stress-induced neural injuries in rats. In both open-field and step-through behavioral tests, the restraint stress-induced neuronal impairments were significantly ameliorated by administration of EGCG or green tea polyphenols (GTPs), which was associated with a partial restoration of normal plasma glucocorticoid, dopamine and serotonin levels. Furthermore, the stress-induced decrease of PKCα and ERK1/2 expression and phosphorylation was significantly attenuated by EGCG and to a less extent by GTP administration. Additionally, EGCG supplementation restored the production of adenosine triphosphate (ATP) and the expression of a key regulator of cellular energy metabolism, the peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α), in stressed animals. In conclusion, PKCα and ERK1/2 signaling pathways as well as PGC-1α-mediated ATP production might be involved in EGCG-mediated protection against stress-induced neural injuries.
Keywords
5-HTphosphorylated extracellular signal-regulated kinase 1/2Protein kinase C αEpigallocatechin-3-gallate (EGCG)PKCαGTPSPGC-1αMPTPEpigallocatechin-3-gallateEGCG1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine5-hydroxytryptamine or serotoninERK1/2pERK1/2Adenosine TriphosphateATPStressAlzheimer's diseaseParkinson’s diseaseCNSDopamineBBBBlood–brain barriercentral nervous systemHPAgreen tea polyphenolsextracellular signal-regulated kinase 1/2Glucocorticoids
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Authors
Xiaoling Zhao, Fengqin Liu, Haimin Jin, Renjia Li, Yonghui Wang, Wanqi Zhang, Haichao Wang, Weiqiang Chen,