| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5738207 | Neuroscience Letters | 2017 | 7 Pages |
â¢Prenatal methamphetamine exposure resulted in decreased aversive effects of nicotine in adult male rats but not in adult female rats.â¢Prenatal methamphetamine exposure did not influence nicotine-induced locomotor activity in either male or female adult rats.â¢Prenatal methamphetamine exposure and gender differentially affected nicotine-induced behaviors such as nicotine-induced conditioned taste aversion and locomotor activity.
The goal of the current study was to assess the effects of prenatal methamphetamine (MA)/saline exposure on nicotine-induced stimulant and aversive effects in both male and female adult rats. The aversive effects of nicotine were assessed using the nicotine-induced conditioned taste aversion model (0.4Â mg/kg, base), while the stimulant effects of nicotine were measured by assessing changes in spontaneous locomotor activity after subcutaneous administration of different doses of nicotine (0, 0.1 & 0.4Â mg/kg, base). The aversive effects of nicotine were significantly decreased in male, but not in female rats with a history of prenatal MA exposure compared to respective saline controls. No influence of prenatal MA exposure was observed on nicotine-induced increase in locomotor activity in either male or female rats. In conclusion, males with a history of prenatal MA exposure may be more vulnerable to nicotine addiction due to a decrease in nicotine-induced aversive effects.
