| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5738323 | Neuroscience Letters | 2017 | 5 Pages |
Abstract
â¢Sleep deprivation enhances the expression of hippocampal 5-HT1A receptors.â¢5-HT induced depression of hippocampal CA1 pEPSPs is larger in SD rats.â¢A 24 or 48 h sleep recovery diminished the effect of 5-HT.
A 12Â h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48Â h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48Â h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
H. Azizi, J. Hwang, V. Suen, N.Z. Kang, R. Somvanshi, R. Tadavarty, U. Kumar, B.R. Sastry,