Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5739378 | Hearing Research | 2017 | 55 Pages |
Abstract
With short postexposure survivals, the remaining SCs often had pathological changes, including: buckled pillar bodies, shifted Deiters' cell (DC) nuclei, detachment of DCs from the basilar membrane and/or splitting of the reticular lamina. These pathological changes appeared to allow endolymph and perilymph to intermix in the fluid spaces of the organ of Corti, damaging additional HCs, SCs and nerve fibers. This mechanism may account for some postexposure degeneration. In ears exposed to moderate noise, some of these SC changes appeared to be reversible. In ears exposed to high-level noise, these changes appeared to indicate impending degeneration.
Keywords
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Sensory Systems
Authors
Barbara A. Bohne, Melissa Kimlinger, Gary W. Harding,