Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5747631 | Ecotoxicology and Environmental Safety | 2017 | 8 Pages |
Abstract
The aim of this study was to evaluate the bioconcentration potential of fluoxetine and its biological effects in Daphnia magna. After 48 h of waterborne exposure, the bioconcentration of fluoxetine in D. magna was determined to be 460.61 and 174.41 L kgâ1 for nominal exposure concentrations of 0.5 and 5 µg Lâ1, respectively. Moreover, various biological endpoints, including physiological responses (filtration and ingestion rates), enzymatic biomarkers related to neurotoxicity [acetylcholinesterase (AChE)] and antioxidant defense [superoxide dismutase (SOD)], and an oxidative stress damage marker [malondialdehyde (MDA)], were assessed. Fluoxetine exposure increased the filtration rate of daphnia, while the ingestion rate was not obviously modified. AChE activity was significantly inhibited, highlighting the neurotoxicity of fluoxetine on D. magna. However, with some alterations in the SOD activity and MDA content, no obvious oxidative damage was observed in D. magna exposed to fluoxetine at the tested concentrations. These results indicate that fluoxetine can be accumulated and consequently induce physiological and biochemical perturbations in D. magna.
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Authors
Jiannan Ding, Hua Zou, Qingqing Liu, Shanshan Zhang, Roger Mamitiana Razanajatovo,