Fundamentals of percutaneous chemical absorption and decontamination

Skin exposure to toxic chemicals continues to cause a range of ill health effects including irritant and allergic dermatitis, allergy and systemic toxicity. Unfortunately, there is little published data on the efficacy of skin cleansers in removing toxic chemicals from the skin. In order to develop strategies to minimize percutaneous absorption, we must start with a fundamental understanding of the skin and the dermal absorption process. By understanding this process, we can better develop effective decontamination solutions.