Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5752158 | Sustainable Chemistry and Pharmacy | 2017 | 4 Pages |
Abstract
The extension of the enzymatic resolution of amines catalyzed by an immobilized lipase in combination with diethyl malonate as acyl donor towards a solvent-free process is described. In such a resolution process the resulting chiral amide was formed with both high conversion and enantioselectivity, and this solvent-free synthetic method turned out to be robust and efficient also at an elevated 50Â mmol-scale reaction, leading to the desired amide with 50% conversion, in 43.5% yield and with excellent enantiomeric excess of 99% ee. This method proceeding at a short reaction time (4.5Â h) opens up a perspective for future development towards a large-scale feasible process technology for the enantioselective synthesis of chiral amines.112
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Authors
Florian Uthoff, Anna Reimer, Andreas Liese, Harald Gröger,