Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5756308 | Environmental Research | 2017 | 5 Pages |
Abstract
Perfluorooctanoic acid (PFOA), a perfluoroalkyl substance, is commonly detected in the serum of pregnant women and may impact fetal development via epigenetic re-programming. In a pilot study, we explored associations between serum PFOA concentrations during pregnancy and offspring peripheral leukocyte DNA methylation at delivery in women with high (n = 22, range: 12-26Â ng/mL) and low (n = 22, range: 1.1-3.1Â ng/mL) PFOA concentrations. After adjusting for cell type, child sex, and income, we did not find differences in CpG methylation in the two exposure groups that reached epigenome-wide significance. Among the 20 CpGs with the lowest p-values we found that seven CpG sites in three genes differed by exposure status. In a confirmatory cluster analysis, these 20 CpGs clustered into two groups that perfectly identified exposure status. Future studies with larger sample sizes should confirm these findings and determine if PFOA-associated changes in DNA methylation underlie potential health effects of PFOA.
Keywords
Related Topics
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Environmental Science
Health, Toxicology and Mutagenesis
Authors
Samantha L. Kingsley, Karl T. Kelsey, Rondi Butler, Aimin Chen, Melissa N. Eliot, Megan E. Romano, Andres Houseman, Devin C. Koestler, Bruce P. Lanphear, Kimberly Yolton, Joseph M. Braun,