| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5788946 | Science Bulletin | 2016 | 9 Pages |
Abstract
An o-nitrobenzyl-based photocleavable antitumor prodrug with a terminal carboxyl group was designed and synthesized. The photolysis properties of the prodrug were investigated by means of 1H NMR, HPLC, UV, and MTT methods. The results showed that the toxicity of the anticancer drug was effectively shielded before release. However, the prodrug effectively regained the antitumor capability against cancer cells by release of 5-fluorouracil when it was exposed to ultraviolet irradiation.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Shuli Mo, Ying Wen, Fengfeng Xue, Haichuang Lan, Yueyuan Mao, Guanglei Lv, Tao Yi,