| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5789009 | Science Bulletin | 2016 | 6 Pages |
Abstract
A label-free colorimetric protocol based on peptide nucleic acid/silver nanoparticles (PNA/AgNPs) has been initially proposed for specific recognition of mRNA. Making use of the controlled silver nanoparticles aggregation/dispersion by PNA/PNA-RNA complex, proto-oncogene c-Myc mRNA detection can be achieved. Moreover, the PNA/AgNPs platform can undergo color change in response to target c-Myc mRNA with single-base-mismatch sensitivity, which could further help in visually identify single nucleotide differences in target genes.
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Authors
Xia Li, Juan Song, Bao-Li Chen, Bing Wang, Rui Li, Hui-Min Jiang, Ji-Feng Liu, Chen-Zhong Li,