| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5806578 | Current Opinion in Virology | 2016 | 8 Pages |
Abstract
- Computational modeling reveals aspects of virus assembly that are not accessible to experiments.
- Coarse-grained models are required to simulate assembly.
- Simulations have demonstrated that viral capsids assemble around RNA by two classes of pathways.
- Simulations have shown how sequence-specific interactions drive selective packaging of viral RNA.
- Simulations identified a potential growth pathway for the mature HIV capsid.
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Authors
Michael F Hagan, Roya Zandi,