| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5806684 | Current Opinion in Virology | 2015 | 5 Pages |
Abstract
The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.
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Authors
Jianzhong Zhu, Arundhati Ghosh, Saumendra N Sarkar,