Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5806708 | Current Opinion in Virology | 2015 | 4 Pages |
Abstract
Dengue virus is the causative agent of dengue virus fever. It infects about 400 million people per year and leads to about 21,000 deaths annually. There is available neither a fully successful vaccine nor a successful drug therapy. Some dengue virus serotypes undergo a temperature dependent conformational change from a 'smooth' form at lower temperatures to a 'bumpy' form at temperatures approaching 37°C, the human body temperature. The bumpy structure is less stable and is probably an intermediate in the formation of a fusogenic virus particle.
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Authors
Xinzheng Zhang, Lei Sun, Michael G Rossmann,