Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5806906 | Current Opinion in Virology | 2013 | 5 Pages |
â¢General presentation of the NCLDV family.â¢Description of the main evolutionary forces acting on their genomes (gene duplications and deletions, gene transfers, movement of mobile elements).â¢NCLDV genomes evolve as genomic accordions with successive steps of expansion and shrinkage.
Nucleo cytoplasmic large DNA virus (NCLDV) superfamily forms a diverse group of viruses that infects a wide range of eukaryotic hosts (e.g. vertebrates, insects, protests, etc.). These viruses are characterized by a huge range in genome size (between 100Â kb and 1.2Â Mb), coupled with an extraordinary diverse genomic repertoire. Here I will review some recent results that shed light on the origin and genome evolution of these viruses, introducing the idea that these viruses evolved using a complex process of genomic accordion that imply successive steps of genome expansions (duplication and gene transfers) and genome reduction, in addition to movement and amplification of diverse mobile genetic elements.