Research paperClinical evaluation of the anti-sweet effects of Gymnema sylvestre extract developed into a dispersable oral tablet

Aim of the studyGymnema sylvestre is a well-known herb noted for its anti-sweet and antidiabetic properties in both traditional and Ayurvedic medicine. The use of modern phyto-pharmaceutical methods may be used to improve both the palatability and efficacy of herbal medicines previously prepared using old traditional methods. The aim of the present study was to develop an improved formulation of G. sylvestre extract that utilized its anti-sweet properties for diet control in obesity with the added advantage of being patient compliant.Materials and methodsThe anti-sweet dosage forms of G. sylvestre extract were prepared as oral dispersing tablets for immediate action. The bitter and unpleasant taste of the plant was masked to improve its palatability. The formulation developed was clinically evaluated for bitter taste masking and anti-sweet efficacy in healthy human volunteers.ResultsThe formulation developed was found to be highly palatable and able to produce an anti-sweet effect for a duration of 30 min. Any sweet foods consumed within this duration of time failed to taste sweet.ConclusionsThe formulation developed may serve as a simple, novel and workable remedy for people to control their sweet cravings, which in turn could help in controlling caloric intake derived from sweet substances and thus help in the control of diabetes and obesity.

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