| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5811315 | Medical Hypotheses | 2014 | 5 Pages |
Abstract
Erectile dysfunction (ED) is a common consequence of radical prostatectomy (RP) and can affect a man's long-term quality of life. Intraoperative manipulation of the neurovascular bundle causes neuropraxia with resultant fibrosis and trabecular smooth-muscle damage. Pioglitazone is an anti-diabetic agent with recognized antifibrotic and vasculoprotective properties, which can protect smooth muscle function. We hypothesize that post-RP pioglitazone therapy can help preserve erectile function.
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Authors
Louis A. Aliperti, Wayne J.G. Hellstrom,