Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5811547 | Medical Hypotheses | 2014 | 17 Pages |
Abstract
Vitamin B12 (Cbl) deficiency may cause hematologic and neurologic dysfunction. Replacement therapy is effective in correcting hematologic abnormalities and improving neurologic symptoms. Cbl is known to have antioxidant activity. This antioxidant activity may antagonize the effects of chemotherapeutics (i.e. genotoxic effects of paclitaxel) on tumor DNA. We claim that Cbl replacement should be done more cautiously in patients receiving cytotoxic chemotherapy.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
Orhan Onder Eren, Mehmet Akif Ozturk, Ozlem Uysal Sonmez, Basak Oyan,