| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5812043 | Medical Hypotheses | 2013 | 4 Pages |
Abstract
Palmitoylethanolamide (PEA) is a fatty acid amide showing some pharmacodynamic similarities with Î9-tetrahydrocannabinol, the principal psychoactive compound present in the cannabis plant. Like Î9-tetrahydrocannabinol, PEA can produce a direct or indirect activation of cannabinoid receptors. Furthermore, it acts as an agonist at TRPV1 receptor. The hypothesis is that PEA has anti-craving effects in cannabis dependent patients, is efficacious in the treatment of withdrawal symptoms, produces a reduction of cannabis consumption and is effective in the prevention of cannabis induced neurotoxicity and neuro-psychiatric disorders.
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Authors
M. Coppola, R. Mondola,