Are uterine leiomyoma a consequence of a chronically inflammatory immune system?

The proposed hypothesis is that leiomyomas are caused in part by a systemic immune milieu that is chronically inflammatory - one that predominates in T helper 17 (Th17) cytokines. Inflammation can be problematic if it is not well regulated. Should an inflammatory imbalance be demonstrated to be associated with leiomyoma development and growth, this would provide an avenue for development of preventative treatments (e.g., focus on anti-inflammatory pathways), which would substantially reduce the morbidity costs of these tumors and reduce a known health disparity.