| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5812501 | Medical Hypotheses | 2012 | 4 Pages |
Abstract
Epidemiological, experimental and clinical studies support a role for uric acid in acute kidney injury (AKI). We discuss how the conventional role of uric acid in AKI has now evolved from intratubular crystal deposition to pro-inflammatory, anti-angiogenic and immunological function. Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways.
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Authors
A. Ahsan Ejaz, Bhagwan Dass, Ganesh Kambhampati, Noel I. Ejaz, Natallia Maroz, Gurjit S. Dhatt, Amir A. Arif, Chirag Faldu, Miguel A. Lanaspa, Gaurav Shah, Richard J. Johnson,