Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5812760 | Medical Hypotheses | 2012 | 4 Pages |
Abstract
Obesity is a growing epidemic in the United States (US). Obesity has been recognized as a modifiable risk factor for many diverse diseases including diabetes, cardiovascular disease and cancer burden. Common contributors to obesity include a high fat diet, smoking and physical inactivity. Systemic effects of obesity include increased micro-inflammatory molecules such as nuclear factor kappa B (NF-κB) that influence the both endothelial and epithelial layers as well as the supportive stroma. An emerging risk factor for micro-inflammation also includes periodontal disease. These pro-inflammatory states are hypothesized to contribute to diabetes as well as cardiovascular disease and cancer through the direct activation of NF-κB. Therefore, a comprehensive health care strategy would include reduction of diabetes, cardiovascular and cancer risk through the decrease in micro-inflammation.
Keywords
MAP3KDLBCLVCAM-1CLLNHANESMCP-1CXCL8ACSPSAIKKαDFMONF-κBNSAIDSDCADifluoromethylornithineMAPK kinase kinaseProstate specific antigenDeoxycholic acidinterleukinNational Health and Nutrition Examination Surveycoronary artery diseaseNon-steroidal anti-inflammatory drugsCancerAcute coronary syndromebody mass indexBMICADnuclear factor kappa BDiffuse large B-cell lymphomaMaltJUPITERvascular cell adhesion molecule-1CAN
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Authors
Nathaniel S. Rial, Kwan Choi, Tam Nguyen, Branden Snyder, Marvin J. Slepian,