Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5813264 | Neuropharmacology | 2016 | 38 Pages |
Abstract
We found that TKO mice showed resilience to stress-induced anxiety and facilitation in fear extinction. Accordingly, no significant increase was evident in aminergic prefrontal or amygdala GABA release, and no significant acute stress-induced amygdalar dendritic remodeling was observed in TKO mice. Differential GRM7, 5-HT2C, and CRFR1 mRNA expression was noted in the mpFC and BLA between TKO and WT mice. Our data demonstrate that the miR-34 has a critical function in regulating the behavioral and neurochemical response to acute stress and in inducing stress-related amygdala neuroplasticity.
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Authors
Diego Andolina, Matteo Di Segni, Elisa Bisicchia, Francesca D'Alessandro, Vincenzo Cestari, Andrea Ventura, Carla Concepcion, Stefano Puglisi-Allegra, Rossella Ventura,