Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons

Article ID	Journal	Published Year	Pages	File Type
5813283	Neuropharmacology	2016	45 Pages	PDF

Keywords

aCSF FTi HMG-CoA after hyperpolarization α7nAChR NMDAR GGPP FOH GGOH SRC HDAC Aβ FPP PVDF DMSO NMDA receptor SDS-polyacrylamide gel electrophoresis SDS-PAGE Alzheimer's disease long-term potentiation LTP Dimethyl sulfoxide Simvastatin Farnesol AHP artificial cerebral spinal fluid Farnesyl transferase inhibitor histone deacetylases histone acetyltransferases Hippocampus β-amyloid peptides geranylgeraniol HAT NMDA receptors α7 nicotinic acetylcholine receptor

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Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons

Authors

Tingting Chen, Baofeng Zhang, Guoxi Li, Lei Chen, Ling Chen,