Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5813361 | Neuropharmacology | 2016 | 12 Pages |
Abstract
These results demonstrate that the KLF11-MAO pathway is activated by binge ethanol exposure and MAOIs are neuroprotective by preventing the binge ethanol-induced changes associated with this cell death cascade. This study supports KLF11-MAO as a mechanism of ethanol-induced neurotoxicity and cell death that could be targeted with MAOI drug therapy to alleviate alcohol-related brain injury. Further examination of MAOIs to reduce alcohol use disorder-related brain injury could provide pivotal insight to future pharmacotherapeutic opportunities.
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Behavioral Neuroscience
Authors
Jeremy W. Duncan, Xiao Zhang, Niping Wang, Shakevia Johnson, Sharonda Harris, Chinelo Udemgba, Xiao-Ming Ou, Moussa B. Youdim, Craig A. Stockmeier, Jun Ming Wang,