Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5813471 | Neuropharmacology | 2016 | 11 Pages |
Abstract
Sleep disturbances are among the most disabling non-motor symptoms in Parkinson's disease. The pedunculopontine tegmental nucleus and basal ganglia are likely involved in these dysfunctions, as they are affected by neurodegeneration in Parkinson's disease and have a role in sleep regulation. To investigate this, we promoted a lesion in the pedunculopontine tegmental nucleus or substantia nigra pars compacta of male rats, followed by 24Â h of REM sleep deprivation. Then, we administrated a dopaminergic D2 receptor agonist, antagonist or vehicle directly in the striatum. After a period of 24Â h of sleep-wake recording, we observed that the ibotenic acid infusion in the pedunculopontine tegmental nucleus blocked the so-called sleep rebound effect mediated by REM sleep deprivation, which was reversed by striatal D2 receptors activation. Rotenone infusion in the substantia nigra pars compacta also blocked the sleep rebound, however, striatal D2 receptors activation did not reverse it. In addition, rotenone administration decreased the time spent in NREM sleep, which was corroborated by positive correlations between dopamine levels in both substantia nigra pars compacta and striatum and the time spent in NREM sleep. These findings suggest a new circuitry for sleep regulation in Parkinson's disease, involving the triad composed by pedunculopontine nucleus, substantia nigra pars compacta and striatum, evidencing a potential therapeutic target for the sleep disturbances associated to this pathology.
Keywords
REMSDGPiPPTSTNGPEREMDHPGDOPACNREMSubstantia nigra pars reticulata3,4-dihydroxyphenylacetic acidDMSOexternal globus pallidusinternal globus pallidusSNpcSNprStriatumParkinson's diseaseSleep regulationsubstantia nigrasubstantia nigra pars compactatyrosine hydroxylaseNon-rapid eye movement sleeprapid eye movement sleepDopamineDimethylsulfoxideRapid eye movement sleep deprivationPedunculopontine nucleuspedunculopontine tegmental nucleusSubthalamic nucleushomovanillic acidChATHVAcholine acetyltransferase
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Authors
Adriano D.S. Targa, Lais S. Rodrigues, Ana Carolina D. Noseda, Mariana F. Aurich, Monica L. Andersen, Sergio Tufik, Cláudio da Cunha, Marcelo M.S. Lima,