Peroxisome proliferator-activated receptor-Î³ (PPARÎ³) agonist is neuroprotective and stimulates PGC-1Î± expression and CREB phosphorylation in human dopaminergic neurons

Article ID	Journal	Published Year	Pages	File Type
5813565	Neuropharmacology	2016	10 Pages	PDF

Keywords

OCR PPARγ pKa FCCP PGC-1α TFAM NRF1 SOD2 H89 Sirt1 ND1 Sirtuin-1 TRX2 SQ22536 cAMP responsive element-binding protein AC6 peroxisome proliferator-activated receptor-γ coactivator-1α 9-(tetrahydro-2-furanyl)-9H-purin-6-amine HRP CREB SDS CRE TBS 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Mitochondrial DNA MTT ROS SDS-polyacrylamide gel electrophoresis SDS-PAGE Parkinson's disease Tris-buffered saline Thioredoxin reductase 2 mtDNA sodium dodecyl sulfate Superoxide dismutase 2 Nuclear respiratory factor 1 mitochondrial transcription factor A cAMP responsive element Mitochondria Oxygen consumption rate Dopaminergic neurons Hgb Horseradish peroxidase protein kinase A carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone Reactive oxygen species Peroxisome proliferator-activated receptor-γ

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Peroxisome proliferator-activated receptor-Î³ (PPARÎ³) agonist is neuroprotective and stimulates PGC-1Î± expression and CREB phosphorylation in human dopaminergic neurons

Authors

Johanna Mäkelä, Timofey V. Tselykh, Jyrki P. Kukkonen, Ove Eriksson, Laura T. Korhonen, Dan Lindholm,