Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5813953 | Neuropharmacology | 2015 | 9 Pages |
Abstract
It is concluded that glutamate release dependent on P2X7R is increased in cerebrocortical nerve terminals from oxaliplatin-treated rats; the increase is mediated by functional recruitment of Panx1; P2X7R antagonists and Panx1 inhibitors revert oxaliplatin-induced neuropathic pain; Panx1 inhibitors do not alter the oxaliplatin-induced mortality of cancer cells HT-29. The inhibition of Panx1 channel is suggested as a new and safe pharmacological target.
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Authors
Lorenzo Di Cesare Mannelli, Manuela Marcoli, Laura Micheli, Matteo Zanardelli, Guido Maura, Carla Ghelardini, Chiara Cervetto,