| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814066 | Neuropharmacology | 2015 | 5 Pages |
Abstract
GSK588045 dose dependently blocked the signal of the PET ligand [11C]WAY100635, confirming its brain entry and occupancy of 5-HT1A receptors in the primate brain. The estimated EC50 at the post-synaptic heteroreceptors and somatodendritic autoreceptors is similar. 5-HT1 receptor blockade by compounds such as GSK588045 may provide a faster alternate mechanism of antidepressant and anxiolytic action than standard SSRI treatment.
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Authors
Robert A. Comley, Jasper van der Aart, Balázs Gulyás, Martine Garnier, Laura Iavarone, Christer Halldin, Eugenii A. Rabiner,