Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5814218 | Neuropharmacology | 2014 | 6 Pages |
Abstract
The present results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions. However, antidepressant treatment induces a decrease in 5-HT2AR density. This finding suggests that 5-HT2AR down-regulation may be a mechanism for antidepressant effect.
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Authors
Carolina Muguruza, Patricia Miranda-Azpiazu, Rebeca DÃez-Alarcia, Benito Morentin, Javier González-Maeso, Luis F. Callado, J. Javier Meana,