Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice

Article ID	Journal	Published Year	Pages	File Type
5814432	Neuropharmacology	2014	14 Pages	PDF

Abstract

In summary, the data suggest that these novel butterfly derivatives of FTY720 could have considerable implication for future therapies of multiple sclerosis and other autoimmune diseases.

Keywords

TIMP-1 MMP-9 ICAM-1 TIE EAE VCAM-1 PECAM-1 GPCR MOG Fingolimod DMEM LPS PBS SBE Transendothelial resistance S1P AUC BSA DMSO Dulbecco's modified Eagle Medium MAPK bovine serum albumin sphingosine 1-phosphate tissue inhibitor of metalloproteinase-1 Cho Chinese Hamster Ovary tumor necrosis factor-α TER Dimethylsulfoxide blood brain barrier BBB Endothelial cells Smad-binding element TNF-α lipopolysaccharide Matrix metalloproteinase-9 Phosphate-buffered saline area under the curve Multiple sclerosis intercellular adhesion molecule-1 platelet endothelial cell adhesion molecule-1 vascular cell adhesion molecule-1 Permeability mitogen-activated protein kinase myelin oligodendrocyte glycoprotein G protein-coupled receptor

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Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice

Authors

Faik Imeri, Daniel Fallegger, Aleksandra Zivkovic, Stephanie Schwalm, Gaby Enzmann, Kira Blankenbach, Dagmar Meyer zu Heringdorf, Thomas Homann, Burkhard Kleuser, Josef Pfeilschifter, Britta Engelhardt, Holger Stark, Andrea Huwiler,