| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814723 | Neuropharmacology | 2013 | 10 Pages |
Abstract
⺠Broad evidence for a functional interaction in the brain of 5-HT2A and mGlu2 exists. ⺠The heteromerization of 5-HT2A-mGlu2 is discussed to directly account for these findings. âºInteraction of independent receptors could explain the functional cross-talk. ⺠A balanced review of the relevance of 5-HT2A-mGlu2 heteromers is provided. âºQuestions about the existence of the putative heteromers could be addressed by new studies.
Keywords
PFCHTRserotonin receptor 2ALayer V pyramidal cells5-HT2AIEG5-HTmGlu2PIP2PLCmetabotropic glutamate receptor 2GPCRN-methyl-d-aspartateNMDAAMPAR5-hydroxytryptaminePAMmCPPm-ChlorophenylpiperazineEPSCG-protein coupled receptorα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorHeteromerizationSchizophreniaexcitatory postsynaptic currentstransmembrane domainphospholipase Cprefrontal cortexpositive allosteric modulatorHead twitch responseImmediate early genesReceptor cross-talkdopamine receptor 2G protein-coupled receptor
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Hannah K. Delille, Mario Mezler, Gerard J. Marek,