| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814725 | Neuropharmacology | 2013 | 11 Pages |
Abstract
⺠H1152 decreased protein level of mutant ataxin-3-Q79 expressed in 293 cells. ⺠H1152 promoted the degradation of ataxin-3-Q79 by augmenting proteasome activity. ⺠H1152 enhanced ataxin-3-Q79 degradation independently of its ROCK-inhibiting effect. ⺠H1152 reduced ataxin-3-Q79 level in SCA3 affected CNS areas of SCA3 transgenic mice. ⺠H1152 ameliorated pontine neuronal death and ataxic symptom of SCA3 transgenic mice.
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Authors
Hung-Li Wang, Su-Huei Hu, An-Hsun Chou, Shang-Seng Wang, Yi-Hsin Weng, Tu-Hsueh Yeh,