| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814732 | Neuropharmacology | 2013 | 11 Pages |
Abstract
⺠This study uses a naturally occurring model of cognitive aging in the rat. ⺠Basal GTPγS-binding to Gαq/11 is elevated in the aged hippocampus. âºÂ Muscarinic stimulation of [Ca2+]i is blunted in aged hippocampus. ⺠GPCR stimulation of [Ca2+]i is more dependent on ICS in aged hippocampus. ⺠These effects of age are not related to spatial learning impairment.
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Authors
Joseph A. McQuail, Kathleen N. Davis, Frances Miller, Robert E. Hampson, Samuel A. Deadwyler, Allyn C. Howlett, Michelle M. Nicolle,