| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814749 | Neuropharmacology | 2013 | 12 Pages |
Abstract
⺠Intracellular signaling induced by morphine withdrawal in the brain is studied. ⺠Chronic morphine and morphine withdrawal modulate ERK pathway in the rat brain. ⺠Multiple epigenetic modifications are induced by precipitated morphine withdrawal. ⺠Signaling and epigenetic changes are paralleled by early genes expression. ⺠Our results reveal molecular changes underlying opioid withdrawal syndrome.
Keywords
PBSMSK1IEGMecp2VTAERKNACLSVLSINGSLSDdorsal striatumEpigeneticsOpioidsnormal goat serumlateral septumventral lateral septumPhosphate buffered salineactivity-regulated cytoskeleton-associated proteinArcventral tegmental areaNeuroanatomySignal transductionNucleus accumbensmethyl-CpG-binding protein 2Immediate early genesextracellular signal-regulated kinase
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Authors
Alessandro Ciccarelli, Arianna Calza, Francesca Santoru, Fabrizio Grasso, Alessandra Concas, Marco Sassoè-Pognetto, Maurizio Giustetto,