| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814759 | Neuropharmacology | 2013 | 7 Pages |
Abstract
⺠Lurasidone has high affinity for 5-HT7 receptors, a proposed target for depression. ⺠Lurasidone acted antidepressant-like in the tail suspension and forced swim tests. ⺠The effect of lurasidone was absent in mice lacking the 5-HT7 receptor. ⺠In the repeated open-space swim test lurasidone had an effect similar to citalopram. ⺠Lurasidone acts as a 5-HT7 receptor antagonist and can be used as an antidepressant.
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Authors
Lindsay N. Cates, Amanda J. Roberts, Salvador Huitron-Resendiz, Peter B. Hedlund,