Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5814769 | Neuropharmacology | 2013 | 7 Pages |
Abstract
⺠Cognitive-enhancing effects of i.c.v. angiotensin IV (Ang IV) characterized in mice. ⺠Ang IV dose-dependently (0.1-10 nmol) enhances novel object recognition (NOR). ⺠Ang IV enhancement of NOR performance occurs rapidly, but of brief duration. ⺠Ang IV receptor antagonist blocks Ang IV-mediated enhancement of NOR. ⺠Alanine scan of Ang IV suggests three residues contributing to procognitive core.
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Authors
Jason J. Paris, Shainnel O. Eans, Elisa Mizrachi, Kate J. Reilley, Michelle L. Ganno, Jay P. McLaughlin,