| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814782 | Neuropharmacology | 2013 | 9 Pages |
Abstract
⺠Therapeutic doses of botulinum neurotoxin (BoNT) A abolish autonomic transmission. ⺠Clinical potency due to selective cleavage of SNAP-25 used directly in exocytosis. ⺠Partial truncation of SNAP-25 is a feature of BoNT/A protease revealed by chimeras. ⺠Neuronal varicosities are enriched in toxins' acceptors and SNARE targets. ⺠Unique efficacy of /A may underlie prolonged autonomic symptoms in human botulism.
Keywords
TTXSNAREsSV2VAChTBoNTVAMPsEPSCsSNAP-25SNAREaCSFsynaptic vesicle protein 2nAChRDAPIPBS4′,6-diamidino-2-phenylindoleAcetylcholinetetrodotoxinvesicular acetylcholine transporterlight chainartificial cerebrospinal fluidPhosphate-buffered salineNeurotherapeuticsBotulinum neurotoxinautonomic neuronsVesicle-associated membrane proteinsynaptosome-associated protein of 25 kDanicotinic acetylcholine receptor
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Authors
Gary W. Lawrence, Saak V. Ovsepian, Jiafu Wang, K. Roger Aoki, J. Oliver Dolly,