| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5814833 | Neuropharmacology | 2013 | 7 Pages |
Abstract
⺠Use-dependent recovery of NMDAR currents after MK-801 blockade is boosted by Mg2+. ⺠Use-dependent recovery is also accelerated by memantine. ⺠NMDA + Mg2+ can trigger 45% MK-801 dissociation in only 10 min ⺠NMDA + Mg2+ can promote death in neurons with NMDARs 100% pre-blocked by MK-801. ⺠Care should be taken not to overestimate the stability of MK-801 blockade of NMDARs.
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Authors
Sean McKay, C. Peter Bengtson, Hilmar Bading, David J.A. Wyllie, Giles E. Hardingham,