Invited reviewmGlu3 receptor and astrocytes: Partners in neuroprotection

Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation of metabolic and neuroinflammatory processes.Since the discovery of mGlu3 receptors on astrocytes, accumulating evidence supports a role of these receptors not only in maintaining synaptic homeostasis and treating psychiatric disorders but also in promoting astrocyte survival in several pathologic conditions.This review focuses on providing up-to-date knowledge regarding effects of activating astroglial mGlu3 receptors on psychiatric disorders, astrocyte and neuronal survival, and neurodegenerative diseases.This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.

► Astrocytes express mainly mGlu3 and mGlu5 receptors. ► mGlu3 receptors have been mostly associated with protective effects in neurons and astroglia. ► Protective actions of mGlu3 receptors derive from glutamate uptake and trophic factors release. ► mGlu3 receptor agonists prevent astrocyte death induced by OGD and nitric oxide. ► Astroglial mGlu3 receptor activation exerts neuroprotection against β-amyloid.